Induction of Lysosomal Enzymes by Phagocytosis
نویسنده
چکیده
Recent morphologic and biochemical studies of macrophage lysosomes (1, 2) have shown that pinocytic vesicles are converted into secondary lysosomes in the centrosphere region of the cytoplasm by fusion with Golgi vesicles and/or preexisting secondary lysosomes. Environmenta l molecules which increase the rate of pinocytic activity result in both increased numbers of lysosomes and increased levels of lysosomal enzymes. The mechanism by which endocytosis stimulates the formation of macrophage lysosomes is still obscure. This report will concern the role of membrane interiorization and the nature of interiorized substrate on the control of lysosomal hydrolases.
منابع مشابه
In Vitro Induction of Lysosomal Enzymes by Phagocytosis
The in vitro induction of lysosomal enzymes by phagocytosis was demonstrated in cultivated mouse peritoneal macrophages. The contribution of each of several steps in the endocytic process to enzyme induction was examined. The enzymatic response after the uptake of equal numbers of erythrocytes (RBC) and nondigestible particles were compared. Phagocytosis of RBC produced a marked increase in the...
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